Best Underdog Bets For Week 1 Of The 2021-2022 NFL Season

• The New York Giants are minor -105 underdogs against the Denver Broncos.
• The Seattle Seahawks have +125 odds against the new-look Indianapolis Colts.
• The Miami Dolphins are +110 as betting underdogs against the New England Patriots.

LAS VEGAS – Week 1 of the 2021-2022 NFL season is loaded with quality matchups as well as some viable betting underdogs who can win their games.

Most notably, the Seattle Seahawks, New York Giants and Miami Dolphins are all underdogs in their opening game of the upcoming season.

New York Giants vs Denver Broncos

The New York Giants should be much improved from a year ago. Saquon Barkley is healthy, Kenny Golladay and Adoree' Jackson were added in free agency and Kadarius Toney and Azeez Ojulari were acquired through the draft. Despite all of this, the team remains the betting underdog against the Denver Broncos.

Giants vs Broncos Week 1 Moneyline Odds

• New York Giants -105
• Denver Broncos -115

The Broncos have plenty of question marks moving into the new season. First and foremost, there isn't a set starting quarterback between Drew Lock and Teddy Bridgewater.

While things look to be coming together for the Giants, not much seems to be improving for the Broncos. NFL betting followers should feel confident in taking the slight underdog in this spot.

Seattle Seahawks vs Indianapolis Colts

When Week 1 kicks off, the Seattle Seahawks will be underdogs against the Indianapolis Colts.

The Seahawks went 12-4 last year and have largely improved since aside from possibly wide receiver and cornerback depth. However, there's a fair argument to be made that when you have Russell Wilson, wide receiver depth isn't needed that much.

Seahawks vs Colts Week 1 Moneyline Odds

• Seattle Seahawks +125
• Indianapolis Colts -145

It's tough to argue with the thought process of if sports betting sites are going to offer a Wilson-led team as an underdog, it's instantly worth the play. Add on the fact that the Colts will have Carson Wentz making his first career start with the team in his first time with a new system, and it seems even better for Seattle.

This is one of those times where it makes you think whether the sportsbooks know something that the public doesn't because the odds seemingly make no sense. However, most of the time it's better to not overthink bets.

Miami Dolphins vs New England Patriots

The AFC East, behind the Buffalo Bills, is a bit of a mess.

The Miami Dolphins and New England Patriots are thought to be the contenders for second place in the division and they will meet in Week 1 in what could be a telling game.

The Patriots will be returning a couple of players after seeing a league-high number of players opt-out last season while the Dolphins look to continue improving and working towards contender status.

Dolphins vs Patriots Week 1 Moneyline Odds

• Miami Dolphins +110
• New England Patriots -130

The Patriots will either have an aging and struggling Cam Newton or a rookie QB in Mac Jones running the offense while Miami will have Tua Tagovailoa who should be getting more comfortable in the system.

This is honestly a game that could go either way, but considering the value, it's worth the risk. Miami could very well start off the season with a big division win of New England.