Can The Spread-Crushing Colts Cover Against The 49ers?

• The San Francisco 49ers face off against the Indianapolis Colts for Sunday Night Football.
• The 49ers have a 2-6 ATS record at home since 2020, the worst in the league.
• The Colts have an 8-4 ATS record on the road since 2020, the fifth-best in the league.

SAN FRANCISCO - The San Francisco 49ers host the Indianapolis Colts for Sunday Night Football, which will kick off at 8:20 p.m. EST on Sunday on NBC.

The Colts enter the game with a 2-4 record, which is good for second place in the woeful AFC South.

The 49ers, who were expected to be one of the top teams in the NFL in the preseason, have struggled with injuries, and have a 2-3 record after their Week 6 BYE.

Indianapolis Colts @ San Francisco 49ers Odds

• Indianapolis Colts +4.0 (-110)
• San Francisco 49ers -4.0 (-110)

The Indianapolis Colts may be 2-4 straight up, but they have a 4-2 record against the spread this season.

Since 2020, the Colts have an 8-4 record against the spread on the road, which makes them the fifth-best road team ATS in this timeframe.

The San Francisco 49ers, meanwhile, are one of the worst teams in the league against the spread this season, with a 1-4 ATS record in their five games on the year.

Since 2020, the 49ers are the team with the worst home record in the league against the spread, covering only twice in eight home attempts.

They had fewer home attempts than anyone else on the list, as they relocated to Arizona partway through the 2020 NFL season due to COVID-19 restrictions.

Indianapolis Colts Vs. San Francisco 49ers O/U Odds

• OVER 44.5 (-110)
• UNDER 44.5 (-110)

In terms of O/U records, Indianapolis is split down the middle, with three OVERs and three UNDERs hitting this season.

San Francisco is sitting as close to that as they can get in their five games played, with two OVERs and three UNDERs.

Since 2020, Indianapolis has hit the over 13 times and failed to do so 10 times, while San Francisco has a 10-11 O/U record.

Notably, in the 49ers' last five games after a BYE week, the UNDER has a 5-0 record.

However, in their last six road games that the Colts have played, the OVER has hit five times.

NFL betting fans have a lot to consider with this matchup and while the spread trends seem notable, it’s important to remember that past performances are not a guarantee of future results.